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DTSTAMP:20260818T202031Z
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DTSTART:20260623T090000Z
DTEND:20260624T170000Z
DESCRIPTION:## Overview\nA protein's 3D structure determines its function\,
  but experimental methods like X-ray crystallography and cryo-EM are slow\
 , expensive\, and can't keep pace with the billions of sequences from mode
 rn genomics. Recent AI-based tools like AlphaFold2 and AlphaFold3 have cha
 nged this\, offering predictions that often reach experimental accuracy. N
 ow many life scientists face a different challenge: knowing how to run the
 se methods effectively and when to trust the results. \n\nThis two-day\, h
 ands-on workshop gives life science researchers practical skills for using
  modern protein structure prediction tools in their own work. Participants
  will learn to run AlphaFold2 via the user-friendly ColabFold interface\, 
 and AlphaFold3 through AlphaFold Server. Beyond just running predictions\,
  participants will learn how to critically evaluate their results using co
 nfidence metrics such as pLDDT\, PAE\, and ipTM\, and how to relate these 
 scores to concrete biological questions. \n\n## Audience\nThis course is d
 esigned for PhD students\, postdoctoral and other researchers in the life 
 sciences from both academia and industry who wish to apply computational s
 tructure prediction to their research but have little to no prior experien
 ce in bioinformatics. \n\n## Learning outcomes\nAt the end of the course\,
  the participants are expected to:\n* Execute AlphaFold2 via ColabFold to 
 predict structures of monomers and protein complexes. \n* Generate AlphaFo
 ld3 via AlphaFold Server to model interactions with DNA\, ligands\, and ot
 her molecules. \n* Evaluate when to use AlphaFold2 or AlphaFold3 for a giv
 en biological question and differentiate the main limitations of each. \n*
  Analyze metrics such as pLDDT\, PAE\, pTM and ipTM to assess the quality 
 and reliability of predicted structures. \n* Interpret and eximine predict
 ed models in SWISS-MODEL's Structure Assessment tool to support interpreta
 tion of their results.  \n\n## Prerequisites\n##### Knowledge / competenci
 es\nThis course is designed for beginners.\n##### Technical\nYou are requi
 red to bring your own laptop. More instructions will be communicated to th
 e course participants.\n## Schedule\n\n**Day 1** 9:00 -17:00\n\n**Foundati
 ons &amp\; Monomers**\n* Introduction: Protein structure prediction histor
 y\, AlphaFold2\, relevant concepts (MSAs\, Evoformer)\, limitations \n* Pr
 actical: Protein monomer prediction using AlphaFold2 \n* Practical: Using 
 SWISS-MODEL's Structure Assessment tool for prediction visualization and i
 ntroduction into AlphaFold Database \n* Interpreting confidence scores \n\
 n**Day 2** 9:00 -17:00\n\n**Advanced Topics &amp\; Complexes**\n* Practica
 l: Advanced AlphaFold2 topics - protein complexes and conformational sampl
 ing \n* Introduction to AlphaFold3 \n* Practical: Using AlphaFold3 \n\n\n\
 n## Application\n\nThe registration fees for academics are **200 CHF** and
  **1000 CHF** for for-profit companies.\n\nWhile participants are register
 ed on a first come\, first served basis\, exceptions may be made to ensure
  diversity and equity\, which may increase the time before your registrati
 on is confirmed.\n\nYou will be informed by email of your registration con
 firmation. Upon reception of the confirmation email\, participants will be
  asked to confirm attendance by paying the fees within 5 working days.\n\n
 Applications close on *09/06/2026*. Deadline for free-of-charge cancellati
 on is set to *09/06/2026*. Cancellation after this date will not be reimbu
 rsed. Please note that participation in SIB courses is subject to our [gen
 eral conditions](https://www.sib.swiss/training/terms-and-conditions).\n\n
 ## Venue and Time\nThis course will take place at the University of Basel.
 \nThe course will start at 9:00 CET and end around 17:00 CET.\nPrecise inf
 ormation will be provided to the registered participants in due time.\n\n\
 n## Additional information\nCoordination: Valeria Di Cola\, SIB Training G
 roup.\n\n\nA **Certificate of Attendance** will be sent provided you were 
 present at the course\, whereas a **Certificate of Achievement** recommend
 ing 0.5 ECTS will be sent provided you passed the exam. \n\n\nYou are welc
 ome to register to the SIB courses mailing list to be informed of all futu
 re courses and workshops\, as well as all important deadlines using the fo
 rm [here](https://lists.sib.swiss/mailman/listinfo/courses).\n\n\nSIB abid
 es by the [ELIXIR Code of Conduct](https://elixir-europe.org/events/code-o
 f-conduct). Participants of SIB courses are also required to abide by the 
 same code.\n\n\nFor more information\, please contact [training@sib.swiss]
 (mailto://training@sib.swiss).
SUMMARY:AlphaFold for protein structure prediction
URL;VALUE=URI:https://www.sib.swiss/training/course/20260623_ALPHA
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