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DTSTAMP:20260902T230402Z
UID:57ff603d-c6d8-46f7-bbbe-47dd79c3dd5f
DTSTART:20180822T150000Z
DTEND:20180822T170000Z
DESCRIPTION:### Overview of Genome Wide Association Studies and study desig
 ns\n\nThe second of a series of seven online lectures for Genome Wide Asso
 ciation Studies (GWAS) will provide a basic overview on genome-wide associ
 ation studies (GWAS). This is timely with the H3Africa genotyping data bec
 oming available for several of the H3Africa research groups. To enable gen
 omic research\, the H3Africa Consortium had to build some of its own resou
 rces. This has involved sequencing whole genomes from selected under-repre
 sented African populations\, analyzing the data to identify common genetic
  variation across major groups and developing a unique GWAS array\, enrich
 ed for common African variation. The H3Africa SNP genotyping array\, is cu
 rrently the best-suited array available for African genome-wide associatio
 n studies.\n\nWhat does it take to develop a genome study to understand ge
 netic and environmental contributions to complex disease traits? This GWAS
  lecture will cover the research process from protocol development to data
  quality control and GWAS analysis approaches. It will include the two mai
 n study designs:\n\n    Case : control (e.g. diabetes\, hypertension\, kid
 ney disease)\n    Continuous trait (e.g. LDL-Cholesterol\, body mass index
 \, height) GWAS.\n\nI will discuss the basic building blocks of a GWAS stu
 dy\, the different study designs\, power of a study to detect genetic asso
 ciation (based in sample size\, allele frequency and expected effect size)
 \, and replication studies. The advantages and disadvantages of doing GWAS
  in African populations will be discussed.
SUMMARY:H3ABioNet 2018 Genotyping Chip Data Analysis and GWAS lecture serie
 s - Lecture 2
URL;VALUE=URI:https://www.youtube.com/watch?v=4_-pxWFUpfU&list=PLcQ0XMykNhC
 QJPz0amnbz9BPM4Bu0Nkgf
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